Dukurikije imibare ya Zhiliwo Big Data Platform, impuzandengo yingaruka zo kwerekana impapuro za Foregene SCI muri Gashyantare 2022 ni 5.8, naho ingaruka zikomeye ni 8.947.
Binyuze mu isesengura mibare yumubare wimpapuro za SCI zibicuruzwa bya Foregene mumyaka, usanga inzira yo gukura igaragara.
Foregene Co., Ltd yashinzwe mu 2011. Ni uruganda rukora ibinyabuzima ruhuza R&D, umusaruro, kugurisha na serivisi zabakiriya.Kuva yashingwa, yibanze ku iterambere rya tekinoroji ya molekuline n’utugingo ngengabuzima, ibicuruzwa na serivisi, inatanga isuku ya nucleic aside, gutahura aside nucleique hamwe n’ibindi bisubizo ku bakoresha benshi.Ibicuruzwa byubushakashatsi byubushakashatsi birimo urutonde rwo kweza RNA, urukurikirane rwo kweza ADN, urukurikirane rwa RT / RT-PCR, urukurikirane rwa PCR, urukurikirane rwa PCR, urukurikirane rwa RT-qPCR hamwe na "Sui" y'ibikoresho bifitanye isano na molekile.Ibicuruzwa byakoreshejwe cyane mubushakashatsi bwibanze mubumenyi bwubuzima, ubuvuzi, ubuhinzi, imiti n’ibidukikije.Abakiriya bari muri kaminuza, ibigo byubushakashatsi, ibitaro nibindi bice.
ZhiLiaowo yahisemo inyandiko 6 zatsindiye amanota menshi ya Foregene muri Gashyantare kugirango abashakashatsi babone, kugirango barusheho gusobanukirwa no kumenyera ibicuruzwa bya Foregene.
Umutwe w'ingingo: Gukomera kwa Substrate bigenga gutandukanya ingirabuzimafatizo ya pluripotent ingirangingo mu mutima wa valve endothelia
DOI: 10.1016 / j.actbio.2022.02.032
Igihe cyo kurekura: 2022-2-27
Foregene
Ubuvanganzo bwavuzwe
Ingingo Umutwe: Kumenya Imikono ya Mitochondrial Proteome Yifatanije na Pathogenezesi ya Hypertension ya Pulmonary Arterial Hypertension muburyo bw'imbeba
DOI: 10.1155 / 2022/8401924
Igihe cyo kurekura: 2022-2-21
Ubwanditsi bw'umwanditsi: Ishami rya farumasi, Ibitaro byambere bishamikiye kuri kaminuza yubuvuzi ya Sinayi.
Abstract: Indwara yumuvuduko ukabije wamaraso (PAH) nindwara ikomeye kandi itera imbere yibasira umutima nibihaha kandi nikibazo cyubuzima ku isi kibasira abantu na societe.Muri ubu bushakashatsi, hubatswe icyitegererezo cyimbeba ya PAH iterwa na monocrotaline (MCT).Poroteyine za mitochondrial ya buri tsinda ryimbeba zagenwe hakoreshejwe tekinoroji ya proteomic idafite label.Hashingiwe ku iyubakwa no gukungahaza imiyoboro ya poroteyine-poroteyine (PPI), 19 genoside ya mitochondial igenzurwa na genoside 123 za mitochondial zagenzuwe mu mbeba za PAH.Byongeye kandi, mu bushakashatsi bwigenga bwa cohort dataset, ibisubizo byagaragaje ko ingirabuzimafatizo 6 zagengwa na mitochondrial genes 3 na genoside ya mitochondial yagabanutse mu buryo butandukanye mu ngingo z’ibihaha z’imbeba za PAH.Ibishobora kuba miRNA yibasiwe na genoside yo hagati ya mitochondrial genes byahanuwe kurwego rwa transcriptome ukoresheje ububiko bwa RNAInter.Ubushakashatsi bwagaragaje kandi bortezomib na carfilzomib nk'imiti ishobora kuvura PAH.Hanyuma, ubu bushakashatsi butanga urumuri rushya kuri biomarkers ningamba zo kuvura PAHs.
Foregene
Ubuvanganzo bwavuzwe
RT Byoroshye II (Master Premix kumurongo wambere cDNA Synthesis Kuri qPCR)
Cataloge No.: RT-01021
Ibisobanuro: 50 × 10 μL rxns
Ingingo Umutwe: Igihombo cya PTEN gitanga sensibilité kuri rapalogs muri kanseri yimpyiko isobanutse
DOI: 10.1038 / s41401-022-00862-1
Igihe cyo kurekura: 2022-2-14
Abanditsi: Ishami rya Farumasi, Ibitaro bya Nanfang, Kaminuza y’Ubuvuzi y’Amajyepfo, Guangzhou, Ubushinwa
Abstract: Rapalog ni allosteric mTORC1 inhibitor hamwe numuti wemewe wa kanseri yimpyiko isobanutse neza (ccRCC).Ubushakashatsi ukoresheje imirongo myinshi ya ccRCC yumurwayi yerekana ko selile zabuze PTEN zigaragaza hyperensitivite kuri rapalogs.Mu murongo wa selire ya ccRCC idafite PTEN, Rapalogs yabujije ikwirakwizwa ry'utugari mu gutuma G0 / G1 itabwa muri yombi idateye apoptose.Ukoresheje CRISPR / Cas9-yakozwe na selile ya isogenic selile, ubushakashatsi bwemeje isano iri hagati yo gusiba PTEN na hypersensitivite ya Rapallo.Ibinyuranye, gusiba VHL cyangwa chromatin-ihindura genes (PBRM1, SETD2, BAP1, cyangwa KDM5C) ntabwo byagize ingaruka kubisubizo bya selile kubisambo.Imvugo ya ectopique yerekana imikorere ya mTOR ikora (C1483F) yerekanwe mukurwanya PTEN iterwa no gukura kwingirabuzimafatizo, mugihe hashyizweho imiti ya mTOR irwanya imiti (A2034V) yatumaga selile ya ccRCC idafite PTEN ihunga ingaruka ziterwa no gukura.Uturemangingo twa ccRCC tubuze PTEN twarushijeho kumva ingaruka mbi za temsirolimus ku kwimuka kw ingirabuzimafatizo no gukura kw'ibibyimba muri zebrafish n'imbeba za xenograft.Ubushakashatsi bwerekanye ko gusiba PTEN bifitanye isano no kumva rapallo kandi bishobora gukoreshwa nk'ikimenyetso cyo gutoranya imiti ya rapallo ku barwayi ba ccRCC.
Foregene
Ubuvanganzo bwavuzwe
Umutwe w'ingingo: Uburyo butangaje bwa microbiota y'amazi mabi y’umunyu mwinshi hamwe numusemburo wihanganira umunyu no kubishyira mu bikorwa
DOI: 10.1016 / j.jece.2022.107377
Igihe cyo kurekura: 2022-2-12
Igice cyumwanditsi: Ishuri ryubuzima Ubumenyi, Kaminuza isanzwe ya Jiangxi
Abstract: Amazi mabi yumunyu mwinshi ni amazi mabi yinganda afite ibice bigoye, ibinyabuzima bidashobora kwangirika no kuvura ibinyabuzima bigoye.Kugirango hagaragazwe uburyo bwimikorere yumuryango wa mikorobe mugutunganya amazi mabi yumunyu mwinshi hamwe numusemburo wihanganira umunyu, hakozwe ubushakashatsi buranga umuryango wa mikorobe nibidukikije.Igipimo cyo gukuraho imiti ya ogisijeni ikenerwa, NH3 - H na azote yose yazamutse cyane muri WWTP.Ibisubizo bikurikiranye cyane byerekanaga ko biofortification yagize ingaruka zikomeye kumiterere ya mikorobe.Kurwego rwa phylum, amatsinda ya Proteobacteria na Ascomycota yiganje, mugihe kurwego rwubwoko amatsinda ya Paracoccus na Meyeroi yiganje.Meyerella igira uruhare runini mu gutunganya amazi mabi y’umunyu mwinshi, ushobora kuba impamvu nyamukuru yo kunoza uburyo bwo gukuraho umwanda.Byongeye kandi, pH, ogisijeni yashonze, hamwe nubunini bukomeye byari ibintu byingenzi byagize ingaruka ku ruhererekane rw’imiryango ya mikorobe mu gihe cya bioaugmentation, ariko, ubwinshi bwa Meyerrotheca ntabwo bwatewe n’imyuka ihumanya ikirere.Ubu bushakashatsi bwerekanye ku buryo bugaragara impinduka n’imihindagurikire y’imikorere ya mikorobe mu gihe cya bioaugmentation, ndetse n’umubano uri hagati y’imiryango ya mikorobe n’ibidukikije, hashyirwaho urufatiro rukomeye rw’imyororokere nyuma yo gutunganya amazi y’amazi menshi hamwe n’umunyu mwinshi.
Foregene
Ubuvanganzo bwavuzwe
Ingingo Umutwe: Isesengura rya Multi-Omics Nyuma yubuyobozi bwa Vaginal ya bacteroide fragilis mu nkoko.
DOI: 10.3389 / fmicb.2022.846011
Igihe cyo kurekura: 2022-2-16
Ubwanditsi bw'umwanditsi: Laboratoire y'ingenzi ya Sichuan ishinzwe ubuhinzi n’inyamanswa Gutezimbere no guhanga udushya
Abstract: Inzira yimyororokere yinkoko ningingo yingenzi yo gukora amagi.Guhuza cyane hagati yigituba n’ibidukikije bishobora gutera kwibasirwa na bagiteri zitandukanye zitera indwara, bikagira ingaruka ku bwiza bw’imbere n’imbere, ndetse bikongera umubare w’impfu bikanatera igihombo cy’ubukungu.Mu myaka yashize, porotiyotike yazanye inyungu mu bukungu ku bworozi n’inkoko nk’uburyo bwa antibiyotike.Hakozwe iperereza ku ngaruka zo kuyobora ibyara B. fragilis kuri microbiota yinkoko cloacal, transcriptome na metabolome kugirango harebwe akamaro ka B. fragilis.Ibisubizo byerekanaga ko kuvura B. fragilis byagize ingaruka kuri mikorobe ya cloaca.Isesengura rya Transcriptome ryerekanye ko ingirabuzimafatizo zijyanye na immunite CCN3, HAS2, na RICTOR zagenzuwe neza, kandi ingirabuzimafatizo za EDNRB, TOX, na NKX2-3 zagengwaga cyane, kandi DEG nazo zikungahaye mu kugenzura umuriro, metabolisme selile, n'inzira zo gusubiza synaptic.Byongeye kandi, metabolite itandukanye yari ifitanye isano cyane cyane na hormone ya steroid biosynthesis, biosynthesis ya fatty idahagije, hamwe na metabolisme ya arachidonic, kandi ubushakashatsi bwerekanye isano iri hagati ya metabolite itandukanye na gen.Mu gusoza, ubu bushakashatsi butanga ishingiro ryerekana ikoreshwa rya B. fragilis nkibishobora kuba probiotic mu bworozi n’inkoko.
Foregene
Ubuvanganzo bwavuzwe
RT Byoroshye II (Master Premix kumurongo wambere cDNA synthesis ya qPCR)
Numero ya Cataloge: RT-01031
Ibisobanuro: 25 × 20 μL rxns
Umutwe w'ingingo: Ubwoko butandukanye bwa Echinococcus granulosus sensu lato mu Bushinwa: Ubushakashatsi bwa Epidemiologiya no gusuzuma buri gihe
DOI: 10.1111 / tbed.14469
Igihe cyo kurekura: 2022-2-9
Ubwanditsi bw'umwanditsi: Laboratoire y'ingenzi ya Sichuan ishinzwe ubuhinzi n’inyamanswa Gutezimbere no guhanga udushya
Abstract: Cystic echinococcose (CE) ni indwara ititaweho na tropique zoonotic yatewe na Echinococcus granulosus kandi ikomeje kuba ikibazo gikomeye cyubuzima rusange ku isi.Mu Bushinwa hagaragaye genotypes zizwi cyane za Echinococcus granulosus uretse G4, cyane cyane mu kibaya cya Qinghai-Tibet, kandi ubwoko bwabo butandukanye bwihariye muri kariya karere k'isi.Nkurikije isuzuma rifatika, ibinyabuzima bigize E. granulosa mu gihugu cyanjye ni ibi bikurikira: E. granulosa (G1, G3), 98.3%;Echinococcus intermedius (G5), 0.1%;Echinococcus intermedius (G6, G7), 1,4%;na Kanada Echinococcus (G8, G10), 0.2%.By'umwihariko, G1 yanduye yari 97.7% kandi yaranzwe no kwaguka kwinshi no gukwirakwiza geografiya.Ibyorezo bya Epidemiologiya byerekanaga ko bihagaze neza kandi bifite intungamubiri za E. coli mu ntama na yak kuva mu ntara eshatu zo mu ntara za CE (Sinayi, Sichuan, na Qinghai).Intama (287/406, 70.7%) zagize umubare munini wa cysts zirumbuka kurusha yak (28/184, 15.2%).Mu myaka 29 ishize, mu Bushinwa habaye 51 Echinococcus granulosus cox1 haplotypes.Haplotype ya basekuruza (Hap_2) yagumye kuba haplotype ikunze kugaragara, haplotypes 12 ugereranije wasangaga ari icyorezo, naho haplotypes 9 ziherutse kumenyekana mugihe cyubushakashatsi.Ibyavuye mu bushakashatsi byerekana ko gukingira intama ku gahato hamwe n’ubukangurambaga bwa EG95 bwo gukingira inkwa bihuye neza n’imiterere ya genotype.
Foregene
Ubuvanganzo bwavuzwe
Twandikire:
Maggie |Guteza imbere ubucuruzi
Foregene Co, Ltd.
M: + 86-15281067355
URL: www.foreivd.com
Igihe cyo kohereza: Apr-08-2022
