“Imiti ya acide nucleique” ikoresha “acide nucleic,” yerekeza ku bintu nka ADN na RNA bigenzura amakuru akomoka ku moko, nk'ibiyobyabwenge.Ibi bituma hashobora kwibasirwa na molekile nka mRNA na miRNA idashobora kwibasirwa n'imiti gakondo ya molekile ntoya hamwe nibiyobyabwenge bya antibody, kandi hari byinshi byitezwe kuri iyi miti nka farumasi yigihe kizaza.Ubushakashatsi bugaragara burimo gukorwa ku isi yose kuko biteganijwe ko bizatuma habaho ibiyobyabwenge bitari byoroshye.
Ku rundi ruhande, hagaragajwe ko iterambere ry’imiti ya acide nucleique ifite ibibazo byo gutsinda, harimo “(i) ihungabana rya molekile ya acide nucleique mu mubiri,” “(ii) impungenge ziterwa n’imiti mibi,” na “(iii) ingorane muri gahunda yo gutanga ibiyobyabwenge (DDS).”Nanone, amasosiyete y’Abayapani asigaye inyuma mu iterambere ry’imiti ya acide nucleique kubera kwiharira patenti yiganjemo aside nucleic n’amasosiyete yo mu Burayi no muri Amerika, bigatuma habaho kwivanga mu iterambere ry’Ubuyapani.
Ibiranga imiti ya acide nucleic
"Imiti ya acide Nucleic" ni igisekuru kizaza cya tekinoroji yo kuvumbura imiti ifite uburyo butandukanye rwose nibikorwa bya farumasi.Iragaragaza kandi ubushobozi bwo guhingurwa byoroshye kuri molekile zingana kandi nubushobozi bwo kwerekana imikorere numutekano urenze uw'imiti ya antibody.Bitewe nibi biranga, harateganijwe ko imiti ya acide nucleique izashyirwa muri kanseri hamwe n’indwara zishingiye ku murage wasangaga bigoye kuvurwa, ndetse no mu ndwara nka ibicurane na virusi.
Ubwoko bw'imiti ya acide nucleic
Umuti wa acide nucleique ukoresha ADN na RNA urimo iyibasira acide nucleic murwego aho poroteyine ikomatanyirizwa muri ADN ya genome (nka mRNA na miRNA) hamwe nibitera poroteyine.
Ubwoko nibiranga imiti ya acide nucleic (imiti yo gukumira no kuvura)
Hariho imiti ya acide nucleic ifite ubwoko butandukanye nibiranga ukurikije intego hamwe nuburyo bwo gukora.
Andika | Intego | Urubuga rwibikorwa | Uburyo bwibikorwa | Incamake |
siRNA | mRNA | Imbere muri selire (cytoplasme) | mRNA | RNA ikubye kabiri hamwe na clavage ya mRNA homologous to theikurikiranye (siRNA), umusatsi umwe RNA (shRNA), nibindin'ingaruka ukurikije ihame rya RNAi |
miRNA | microRNA | Imbere muri selire (cytoplasme) | Gusimbuza microRNA | RNA ikubye kabiri, miRNA yumusatsi umwe RNAcyangwa kwigana kwayo gukoreshwa mugushimangira imikorere ya miRNA yangiritsen'imivurungano |
Antisense | mRNA miRNA | Imbere muri selire (muri nucleus, cytoplazme) | gutesha agaciro mRNA na miRNA, kubuza gutera | RNA / ADN imwe-imwe ihuza intego mRNAna miRNA gutera gutesha agaciro cyangwa kubuzwa,cyangwa ibikorwa byo gusimbuka exon mugihe utera |
Aptamer | Poroteyine (poroteyine idasanzwe) | Hanze y'akagari | Kubuza imikorere | RNA / ADN imwe imwe ihuza poroteyine igenewemuburyo busa na antibodies / ADN |
Kuriganya | Poroteyine (ibintu byandikirwa) | Imbere muri selire (muri nucleus) | Kubuza kwandukura | ADN ikubye kabiri hamwe nurutonde rumwe ruhuza urubugakubintu byo kwandukura, bihuza nibintu byandikirwaya gene yibasiwe kugirango ihagarike gene igenewe |
Ribozyme | RNA | Imbere muri selire (cytoplasme) | RNA | RNA imwe-imwe hamwe na enzyme imikorere yo guhuza no gukuramointego ya RNA |
CpG oligo | Poroteyine (reseptor) | Ubuso bwakagari | Immunopotentiation | Oligodeoxynucleotide hamwe na CpG motif (ADN imwe imwe) |
Ibindi | - | - | - | Umuti wa acide nucleiques usibye ibyo byavuzwe haruguru bikora kurikora ubudahangarwa bw'umubiri, nka PolyI: PolyC (RNA ikubye kabiri)na antigen |
Igihe cyo kohereza: Nyakanga-25-2023