Abakiriya b'ishuri ry'ubuzima, kaminuza ya Sichuan basohoye impapuro zatsindiye amanota menshi bakoresheje ibicuruzwa bya Foregene, bifite ingaruka 17.848

Vuba aha, itsinda rya Song Xu ryo mu Ishuri Rikuru ryUbumenyi bwa kaminuza ya Sichuan ryasohoye urupapuro rwitwaIbintu bya coagulation VII, IX na X ni poroteyine za antibacterial anti-bacteri zirwanya imiti ya Gram-mbi ya bagiteri mu bushakashatsi bwakagari.

Ubushakashatsi bwakagari nikinyamakuru mpuzamahanga cyasohowe hamwe n’ishuri ry’ubumenyi ry’Ubushinwa hamwe n’itsinda ry’Abongereza ryita ku bidukikije, ryemewe cyane mu masomo.

Iyi ngingo imaze gusohoka, yahise itera sensation muri academiya.Kugeza ubu, ibisubizo by’ubushakashatsi byakiriwe n’ibitangazamakuru byinshi nka Xinhua News Agency, World Wide Web, Phoenix Net, Metropolis y'Amajyepfo Daily,Ikibaya cyibinyabuzima, Ikinyamakuru Daily Daily Mail, Ubumenyi bwa buri munsi bwabanyamerika, EurekAlert1!, Kamere ya Springer, Phys.org, nibindi., BioMedCentral nibindi binyamakuru bizwi bifite raporo nyinshi, kandi isi yose yitaye kubisubizo byubushakashatsi biracyiyongera.

Iyo ngingo yerekanye ko ibintu bitatu bya coagulation VII, IX na X bigira uruhare mu itangizwa rya coagulation cascade ni ubwoko bushya bwa poroteyine ya endogenous host antogenacterial, ni ukuvuga ibintu bya coagulation VII, IX na X bifite uruhare runini mugikorwa cya coagulation.Irashobora kandi kurwanya kurwanya bacteri za Gram-mbi, harimo "super bacteria" zirwanya cyane nka Pseudomonas aeruginosa na Acinetobacter baumannii.

Indirimbo Xu, umwanditsi uhuye n'iyi ngingo, yagize ati: “Mu bihe byashize, wasangaga abantu benshi bemeza ko ibintu bishobora gutera trombose, ariko ubu bushakashatsi bwerekanye ko ibintu bya coagulation nabyo bigira ingaruka zidasanzwe zo kuboneza urubyaro.Nibintu byambere byavumbuwe murugo no mumahanga. ”

Amavu n'amavuko

Nkuko twese tubizi, kurwanya bagiteri byabaye ikibazo gikomeye cyubuzima rusange bwisi yose.Amakuru afatika yerekana ko buri mwaka abantu bagera kuri miriyoni bapfa bazize indwara ziterwa na bagiteri zanduza ibiyobyabwenge ku isi.Niba nta gisubizo cyiza, umubare w'impfu buri mwaka guhera 2050 uzaba miliyoni 10.

Gukoresha antibiyotike, hamwe nubushobozi buhebuje bw’ubwihindurize bwa bagiteri, byatumye bagiteri zimwe na zimwe zitera indwara zashoboraga kwicwa n’imiti ya antibacterial zidashobora kurwanya ibiyobyabwenge, ziba “bacteri super” zidashobora kurimburwa.

Byongeye kandi, ugereranije na Gram-positif ya Gram (Gram +), bagiteri mbi (Gram-) ziragoye kuyica bitewe nuko habaho membrane yo hanze (igice kinini ni LPS, alias endotoxin, lipopolysaccharide).Igice cyo hanze ni ibahasha igizwe na selile y'imbere, urukuta ruto ruto hamwe na selile yo hanze.

Amateka yubushakashatsi

Itsinda rya Song Xu ryari ryize ku ngaruka ziterwa na coagulation ku kuvura ibibyimba bibi, ariko mu 2009, byavumbuwe mu buryo butunguranye ko ibintu bishobora kwanduza bagiteri.Kugirango dusobanure uburyo bwa bagiteri ziterwa na coagulation, umushinga umaze imyaka 10 uhereye ubushakashatsi butangiye kugeza impapuro zisohotse.

Byabonetse

Mu mwaka wa 2009, abashakashatsi bavumbuye ku bw'impanuka ko ibintu bya coagulation VII bishobora kurwanya Escherichia coli mu bintu birenga icumi bya coagulation.

Escherichia coli ni iya Gram-mbi ya bagiteri.Ubu bwoko bwa bagiteri buragoye kubyitwaramo, kubera ko ingirabuzimafatizo zifite imbere imbere, urukuta ruto kandi rukomeye.Ibahasha irashobora kwirinda imiti kandi ikarinda bagiteri “kwinjira.”

Tanga igitekerezo

Ibintu bya coagulation ni itsinda rya poroteyine ziri mu maraso zigira uruhare mu gutembera kw'amaraso.Iyo gukomeretsa umubiri wumuntu bitera kuva amaraso, ibintu bitandukanye byo guterana bigenda bikorwa intambwe ku yindi kugirango bibe fibrin filaments, ifunga igikomere hamwe na platine.Niba hari ikintu kimwe cyangwa byinshi byo kubura, kubura indwara ya coagulation.

Abahanga mu bya siyansi babonye ko abarwayi bafite coagulopathie bakunze kwibasirwa n'indwara ya bagiteri nka sepsis na pnewoniya.Iri sano ryatumye batekereza ko ibintu bya coagulation bidashobora kugira uruhare runini mugikorwa cya coagulation, ariko kandi bishobora no kugira ingaruka zo kurwanya indwara.

Kwiga byimbitse

Kugira ngo hakorwe iperereza niba ibintu bya coagulation bishobora guhangana na bagiteri nyinshi za Gram-mbi, abashakashatsi batangiye kwiga uburyo bwimbitse bwa antibacterial.Basanze ibintu bya coagulation VII nibintu bisa na IX nibintu X, izo poroteyine eshatu zirashobora guca mu ibahasha ikomeye ya bagiteri-mbi.

Ibintu byinshi bihari birwanya antibacterial yibasira selile metabolism cyangwa selile selile, ariko ibi bintu bitatu bya coagulation bifite uburyo butandukanye bwibikorwa.Bashobora hydrolyze LPS, igice cyingenzi cya bagiteri yo hanze.Gutakaza LPS bituma bigora Gram-negative bagiteri kubaho.

Komeza

Itsinda ry’ubushakashatsi ryongeye gukora ubushakashatsi kuri ubwo buryo basanga ibyoporoteyine ya coagulation ikora kuri bagiteri ikoresheje urunigi rwurumuri, mugihe urunigi ruremereye nta ngaruka za antibacterial.

Mu bidukikije by’umuco wa laboratoire, abashakashatsi babonye neza ko nyuma yo kongeramo ibintu bya coagulation cyangwa ibice bigize urumuri, ibahasha ya bagiteri yabanje kwangirika, hanyuma mu masaha 4, ingirabuzimafatizo zose zarasenyutse rwose.

Ongeraho ikintu cya VII urumuri rwumucyo kuri Escherichia yumuco,

Ibice bya bagiteri byo hanze byangiritse, selile zirasenyuka

Ntabwo ari Escherichia coli gusa, ahubwo nizindi bagiteri zimwe na zimwe za Gram-mbi zapimwe nazo "zatsinzwe", harimo Pseudomonas aeruginosa na Acinetobacter baumannii.Izi bagiteri zombi zashyizwe ku rutonde n’umuryango w’ubuzima ku isi (OMS) nka bagiteri 12 zibangamira ubuzima bw’abantu kubera kurwanya ibiyobyabwenge.

Kugenzura ubushakashatsi

Ubushakashatsi bw’inyamaswa bukurikira bwagaragaje neza ko ibintu bitera kwifata bikabije.

Abashakashatsi bateye imbeba hamwe n’umubare munini w’ibiyobyabwenge birwanya Pseudomonas aeruginosa cyangwa Acinetobacter baumannii.Nyuma yo gutera inshinge nyinshi zurwego rwa VII urumuri, imbeba zarokotse;mugihe imbeba zo mumatsinda yo kugenzura zatewe na saline zisanzwe zari 24 Bose bazize kwandura nyuma yamasaha.

Nyuma yo kwandura na bagiteri zidasanzwe, kwinjiza ibintu VII urumuri rwumucyo

Irashobora kugira uruhare mukurinda no kuzamura cyane igipimo cyimibereho yimbeba

Akamaro

Kugeza ubu, nta kintu cya antibacterial kizwiho gukora neza na hydrolyzing LPS.

Gutomora uburyo bwa antibacterial bushingiye kuri hydrolysis ya LPS hamwe na antibacterial biranga ibintu bya coagulation, hamwe nubushobozi bwo gutanga izo ngingo ziterwa na coagulation ku rugero runini ku giciro gito, birashobora gutanga ingamba nshya zihenze zo kurwanya bagiteri ziterwa na Gram-negative bacteri Ikibazo cy’ubuzima rusange cyihutirwa.

Mubyongeyeho, iki gikorwa gifite kandi amahirwe menshi yo gukoreshwa mubikorwa byubuvuzi.Kugeza ubu, nta miti izwi ya antibacterial igira ingaruka kuri hydrolyzing LPS.Uhujije imiterere ya antibacterial ya FVII, FIX, na FX kurwanya LPS hamwe n’umusaruro uhenze uhenze cyane, biteganijwe ko hazashyirwaho imiti mishya irwanya “super bacteria”.

Kwagura ingingo

Nubwo abantu bamenyereye cyane izina "super bacteria", ijambo ryabo ryukuri rigomba kuba "bacteri zirwanya imiti myinshi", bivuga ubwoko bwa bagiteri zirwanya antibiyotike nyinshi.

Nkuko byavuzwe haruguru, kwiyongera kwa bagiteri kurubu biterwa ahanini no gukoresha bidafite ishingiro cyangwa gukoresha nabi antibiyotike.Kurugero, gukoresha inshuro nyinshi gukoresha antibiyotike yagutse mugukiza indwara zubuhumekero.

Indwara z'ubuhumekero ni indwara twese tumenyereye.Dukurikije imibare, buri mwana yanduye inshuro zigera kuri 6 kugeza kuri 9 mu mwaka, naho ingimbi n'abangavu bandura inshuro 2 kugeza kuri 4 mu mwaka.

Kubera ko indwara zifata imyanya y'ubuhumekero akenshi ari ishami ryihutirwa, ingorane zikomeye kubaganga byihutirwa mugihe bahuye nabarwayi nuko badashobora kubona amakuru yindwara mugihe gito.Kubwibyo, gutinda kwipimisha bitera indwara bituma abaganga bagomba kwitabaza antibiyotike yagutse (ishobora kuba ingirakamaro).Kubwoko bwinshi bwa bagiteri).

Ubu ni bwo buryo bwo "gukwirakwiza urusobe runini" rw'imiti byatumye habaho ikibazo gikomeye cyo kurwanya imiti ya bagiteri.Kuberako iyo ubwinshi bwimiterere yimitekerereze ikomeje kwicwa, imiti irwanya ibiyobyabwenge izagwira kugirango isimbuze imiterere yoroheje, kandi umubare wa bagiteri urwanya ibiyobyabwenge uzakomeza kwiyongera.

Kubwibyo, niba raporo yukuri yo gutahura indwara ishobora kuboneka mugihe gito kugirango iyobore abaganga mugutanga imiti iboneye, ikoreshwa rya antibiyotike yagutse irashobora kugabanuka cyane, bityo bikagabanya ikibazo cyo kurwanya bagiteri.

Mu guhangana niki kibazo gifatika, itsinda ryubushakashatsi bwa siyanse bwa Fuji ryiyemeje gukora ibikoresho 15 byubuhumekero butera indwara.

Iki gikoresho gikoresha uburyo bwa tekinoroji ya PCR hamwe na tekinoroji ya PCR, ishobora kumenya Streptococcus pneumoniae, methicillin irwanya Staphylococcus aureus, ibicurane bya Haemophilus hamwe nizindi nzira 15 zisanzwe zubuhumekero zo hepfo mumyanya mu isaha imwe.Indwara ya bagiteri irashobora gutandukanya neza bagiteri ikoronije (bagiteri zisanzwe) na bagiteri zitera indwara.Nizera ko bizaba byitezwe kuba igikoresho cyiza cyo gufasha abaganga gukoresha imiti neza.

Imbere ya “super bacteria”, umwanzi rusange wabaturage bose, abantu ntibigeze babifata nabi.Mu rwego rwa siyanse yubuzima, haracyari abashakashatsi benshi nkikipe ya Song Xu bakora cyane kugirango bashakishe kandi bakore bucece mumuhanda kugirango babone ibisubizo bya "super bacteria".

Hano, mu izina ry’urungano rw’ibinyabuzima n’abagenerwabikorwa, Fortune Biotech irashaka kwerekana ko yubaha cyane abahanga bose bitanze ku mbaraga zabo no kubira ibyuya, kandi banasengera ko abantu bashobora gutsinda “super bacteri” vuba bishoboka kandi bakagira ubuzima bwiza kandi bwiza.ibidukikije.