Inkomoko yatanzwe: Umuyobozi w'ikipe ya WuXi AppTec

I Guangzhou, mu Bushinwa, abapolisi bashinzwe gufasha iperereza ry’ibyorezo byasohoye amashusho y’ubugenzuzi: Muri resitora imwe, bombi binjiye mu bwiherero umwe umwe undi nta mibonano mpuzabitsina.Amasegonda 14 gusa yo kubana yemereye virusi nshya yikamba kubona amahirwe, kurangiza ikwirakwizwa.

Ikarita ya WuXi AppTec

Muri Ositaraliya mu majyepfo y’isi, abantu nabo batungurwa no kubona "infection ako kanya".Igihe abashinzwe ubuzima muri New South Wales bakurikiranaga izo manza, basanze umuntu wanduye nibura abantu batatugusa "byanyuze" hanze yubucuruzi cyangwa iduka rya kawa, byinjira vuba mumwanya umwe, kandi virusi itera ubwandu.

Ibisubizo bya genome ikurikirana kuri sample zizi manza byerekanaga ko coronavirus nshya koyateje ubwandu ni ubw'imiterere ya Delta, akaba aribwo bwoko bushya bwa coronavirus mutant bwavumbuwe bwa mbere mu Buhinde mu Kwakira 2020.Umunyeshuri Zhong Nanshan na we yerekanye mu kiganiro aherutse kugirana n’itangazamakuru ko “umutwaro wa delta ufite umutwaro uremereye,gaze isohotse ni uburozi kandi yanduye cyane“, Kugira ngo amahame akomeye asabwa gusobanura“ umubano wa hafi ”…

Kwangiza isi

Muri Mata na Gicurasi 2021, mu Buhinde habaye umuyaga ukabije w'icyorezo.Dukurikije amakuru yashyizwe ahagaragara na Minisiteri y’ubuzima mu Buhinde,umubare wimanza zimaze kwemezwa kumunsi umwe warenze 400.000 icyarimwe!Nubwo hari ibiterane binini hamwe nizindi mpamvu zibyihishe inyuma, ukuri kudashidikanywaho nuko umubare wabantu banduye Delta mutant ugenda wiyongera vuba.

Hanze y'Ubuhinde, kuva muri Nepal kugera mu majyepfo y'uburasirazuba bwa Aziya, kugera mu gace kanini ku isi, imiterere ya Delta ya mutant nayo yakwirakwiriye mu mezi abiri ashize.

“Impinduka ya Delta niyo yandura cyane iboneka kugeza ubu.Yabonetse mu bihugu / uturere 85 kandi yakwirakwiriye vuba mu bantu badakingiwe.”Umuyobozi mukuru w’umuryango w’ubuzima ku isi Dr. Tan Desai ku ya 25 Kamena Yavuze mu kiganiro n’abanyamakuru.

Dr. Tan Desai, Umuyobozi mukuru w’umuryango w’ubuzima ku isi |ITU Amashusho yaturutse i Geneve, mu Busuwisi, CC BY 2.0, ukoresheje Wikimedia Commons)

Ikibazo cya mbere cyanduye Delta cyagaragaye mu Bwongereza hagati muri Mata.Muri kiriya gihe, nyuma y'amezi make "bahagaritswe", hamwe no gutera imbere gukingira, umubare w'abanduye, ibitaro, ndetse n'impfu zose wagabanutse ku buryo bugaragara, kandi icyorezo gisa n'ikigenda neza.

Ariko, Delta mutant ya mutant yahise ibyara umuvuduko wa gatatu wibyorezo byicyorezo mubwongereza, n'umubare w'imanza nshya ku munsi warenze 8.700.Iyi virusi yakwirakwiriye vuba mu bantu batakingiwe, bituma Ubwongereza busubika gahunda bwabwo bwo gufungura.Mubyukuri,ubu Delta mutant ihindagurika yasimbuye Alpha mutant (ni ukuvuga B.1.1.7 ihinduka rya mutant) yavumbuwe bwa mbere mu Bwongereza, kandi ibaye coronavirus nshya.

Ku mugabane wa Amerika, impinduka za Delta nazo zateye impungenge.Nk’uko ubushakashatsi bwakozwe bwakorewe muri Californiya,umubare w'imanza zatewe na Alpha variant strain, yahoze ari “nyamukuru”, yavuye ku barenga 70% mu mpera za Mata igera kuri 42% mu mpera za Kamena, kandi “kuzamuka” kwa Delta ni yo nyirabayazana.Impamvu nyamukuru y'iri hinduka.Umuyobozi w'ikigo cyo muri Amerika gishinzwe kurwanya no gukumira indwara (CDC) yihanangirije ko mu byumweru bike biri imbere, impinduka ya Delta ishobora guhinduka ubwoko bushya bwa coronavirus muri Amerika.

Umubare wa virusi zitandukanye za COVID-19 (mutant mutant mutant ni icyatsi) |ubutaha.org)

Mu Bushinwa, usibye Guangzhou, habonetse ibibazo by'imiterere ya Delta ya Delta no mu gace ka Shenzhen, Dongguan n'ahandi.Abantu bahanganye imbona nkubone na Delta mutant.

Ntabwo gukwirakwiza gukomeye gusa

Kuva icyorezo gishya cy’ikamba cyatangira mu gihe kirenga umwaka, ubwoko butandukanye bwa mutant bwakunze kwitabwaho cyane, harimo n’umutwe wa Alpha mutant wemejwe bwa mbere mu Bwongereza muri Nzeri 2020, ndetse na Beta mutant (B.1.351) byemejwe bwa mbere muri Afurika yepfo muri Gicurasi 2020., Na variant ya Gamma (P.1) yavumbuwe bwa mbere muri Burezili mu Gushyingo 2020.

Ku ya 11 Gicurasi, Ishami ry'Umuryango w'Abibumbye ryita ku Buzima ryashyize ku rutonde Delta mutant mutant yavumbuwe bwa mbere mu Buhinde nk'uwa kane “Guhindura impungenge”(VOC).Ukurikije ibisobanuro bya OMS, VOC bisobanura“Ukekwaho cyangwa yemeje ko bizatera kwanduza cyangwa uburozi;cyangwa kwiyongera cyangwa guhinduka mubigaragaza indwara zamavuriro;cyangwa gutera impinduka mubisubizo bihari, ingamba zo kuvura, hamwe ninkingo nziza.

Amakuru ariho ava mubigo nkishami ryubuzima rusange bwu Bwongereza (PHE) yerekana koubushobozi bwo kohereza bwa Delta variant strain irarenze 100% kurenza iyambere;ugereranije na Alpha variant strain yazengurukaga kwisi yose mugice cya kabiri cyumwaka ushize, variant ya Delta Ubushobozi bwo kwanduza imbaraga burakomeye, igipimo cyo kwanduza kiri hejuru ya 60%.

Usibye kwiyongera gukomeye mu kwanduza no kwanduza, Feng Zijian, umushakashatsi mu kigo cy’Ubushinwa gishinzwe kurwanya no gukumira indwara, yavuze ko ubwo yatangizaga ibibazo biherutse kuba by’amakamba mashya i Guangzhou, ihindagurika rya Delta “ikindi kintu kiranga nuko igihe cyo gukuramo cyangwa intera intera igufi-mugihe gito).Ibisekuru bitanu cyangwa bitandatu byashize muminsi 10 gusa.”Byongeye kandi, ibisubizo by'ibizamini bya PCR by'icyitegererezo cy’abantu banduye byerekanye ko umutwaro wa virusi wiyongereye ku buryo bugaragara, ari nawo watumye indwara zishobora kubaho.

Mu Bwongereza, aho Delta ihindura 90% by'imanza, ibimenyetso bibanza byerekana kougereranije na Alpha variant, abantu banduye variant ya Delta bakubye inshuro ebyiri kuba mubitaro, bivuze ko ibyago byo kuba mubitaro byiyongereyeho 100%.

Imiterere ihindagurika ya gene itwarwa nubwoko butandukanye bwa coronavirus mutant virusi itera impungenge.Muri byo, Delta mutant strain ifite 13 ihinduka ryimiterere ihindagurika ugereranije na virusi yumwimerere |Ikipe ya WuXi AppTec

Urebye uko genetike ikurikirana ya Delta mutant,ifite impinduka zidasanzwe muri gene ikubiyemo proteine ​​ya spike ya coronavirus nshya, itagira ingaruka ku bushobozi bwo kwanduza virusi gusa, ariko kandi ishobora no gutera ubudahangarwa bw'umubiri..Mu yandi magambo, kutabuza antibodi zakozwe nyuma yo kwandura cyangwa gukingirwa bishobora kugabanya ubushobozi bwo guhuza na Delta.

Akamaro k'urukingo

Imbere ya Delta iteye ubwoba, inkingo zihari zirashobora gutanga uburinzi buhagije?

“Kamere” yasohoye inyandiko y'ubushakashatsi ku ya 10 Kamena.Ibisubizo by'ibizamini byo kutabogama kwa antibody byerekanaga koibyumweru bibiri cyangwa bine nyuma yo gukingirwa byuzuye inshuro ebyiri z'urukingo rwa mRNA neocorona BNT162b2, antibody itabogamye ikorwa mumubiri wumuntu igira ingaruka nziza kuri Delta.Imyitozo iracyafite ingaruka zikomeye zo kubuza.

Gutesha agaciro ibikorwa bya serumu yinkingo kurwanya coronavirus yumwimerere hamwe nubwoko butandukanye bwa mutant harimo na Delta |Reba [1]

Mu rwego rwo guhangana n’ubwoko bubiri bukomeye bwa virusi, Delta na Alpha, butera ibimenyetso COVID-19, uburyo urukingo rushobora kuburinda, Ishami ry’ubuzima rusange bw’Ubwongereza ryatangaje ibyavuye mu bushakashatsi bwakozwe ku isi mu mpera za Gicurasi.

Amakuru yerekana ko nubwo urukingo rufite intege nke zo kurinda umutekano wa Deltaugereranije na Alpha amananiza, irashobora kugabanya cyane ibyago byibimenyetso bishya.Yatewe byuzuye inshinge ebyiri z'urukingo rwa mRNA, ingaruka zo gukingira zishobora kugera kuri 88%;bitandukanye, ingaruka zo gukumira Alpha ni 93%.

Ubushakashatsi bwagaragaje kandi ko niba hatanzwe isasu rimwe gusa ry’urukingo, ubushobozi bwo gukumira imiterere ya mutant bugabanuka cyane.Ibyumweru bitatu nyuma yikinini cya mbere cyinkingo, inkingo zombi zishobora kugabanya gusa ibyago byibimenyetso bishya byikamba byatewe na Delta variant strain 33%, naho ibyago bya Alpha bikagabanukaho 50%, byombi bikaba biri munsi yingaruka zo gukingira byakozwe nyuma yo gukingirwa byuzuye inshuro 2.

Ingaruka zo gukingira inkingo ebyiri nshyashya zirwanya B.1.617.2 na B.1.1.7 mutant mutant |Reba [8]

Ikinyamakuru cy’ubuvuzi cyemewe “The Lancet” cyasohoye andi makuru yaturutse mu ishami ry’ubuzima rusange bw’Ubwongereza ku ya 15 Kamena, yerekana kourukingo rushya rwuzuye urukingo rushya (harimo ubwoko bwinshi bwinkingo) rushobora kugabanya cyane ibyago byo kuba mubitaro.Ubushakashatsi bwerekanye kandi ko byibura iminsi 28 nyuma yo guterwa bwa mbere, ingaruka zo gukumira urukingo zigaragara.

Hashingiwe ku bimenyetso byinshi, OMS n'impuguke zaturutse mu bihugu byinshi babishimangiye inshuro nyinshini ngombwa cyane kurangiza inzira yose yo gukingira inkingo zisaba inshuro ebyiri (cyangwa zirenga), cyane cyane mukurinda COVID-19 nurupfu.

Guhinduka kwa mutation, kurinda bikomeje

Ku bantu bafite igipimo gito cyo gukingirwa, variant ya Delta ifite amahirwe yo gukwirakwira vuba.Ubushakashatsi bushingiye ku ruhererekane rw'amakuru agera ku 20.000 kuva muri Mata yasanzemu bice aho ijanisha ryabaturage barangiza gahunda yose yo gukingirwa ritageze kuri 30%, ikwirakwizwa ryimiterere ya Delta irenze cyane ugereranije n’utundi turere aho igipimo cy’inkingo kirenze iyi ijanisha.

Ubundi bushakashatsi bwerekanye kandi ko itandukaniro rinini ku gipimo cy’inkingo rishobora kuba ryaratumye habaho itandukaniro ry’imibare y’abarwayi n’ibitaro byatewe n’impinduka ya Delta mu turere dutandukanye.

Mugihe coronavirus nshya ikomeje gukwirakwira kwisi yose, byanze bikunze ihinduka rya virusi.Usibye Delta mutant ihindagurika hamwe nubushobozi bukomeye bwo kohereza kugeza ubu,abahanga mu bya siyansi kandi barimo gukurikirana imiterere myinshi ya mutant, harimo n’indi moko irindwi ya mutant yashyizwe ku rutonde rwa “Mutant Strains to Observed” (VOI) n’umuryango w’ubuzima ku isi.

Nigute wakwirinda guhora uhindura imitekerereze mishya ya coronavirus, Dr. Michael Ryan wo muri OMS yizera ati: “Imihindagurikire y’ibinyabuzima irashobora gutera impinduka mu miterere ya virusi, nko kuba ishobora kwanduza abantu, kuba mu bitonyanga igihe kirekire, no kutagaragara cyane.Bizatera kwandura, nibindiAriko izo virusi za mutant ntizahindura ibyo tugiye gukora, ziratwibutsa gufata ingamba zose zo gukingira zishobora gukorwa, kandi tugafata ingamba zikarishye, nko kwambara masike, kugabanya ibiterane, n'ibindi. Twashimangiye inshuro nyinshi ingamba. ”

Muri make, nubwo imiterere ya Delta mutant yongereye ubwandu, igabanya igihe cyo gukuramo, kandi uwanduye ararwara cyane, ariko ntibishobora kwirindwa rwose.Yaba inkingo nkuko bisabwa, cyangwa ingamba nka masike no kwigunga, biteganijwe ko izagenzurwa neza.Mu guhangana na Delta mutant, gahunda mubyukuri iri mumaboko yacu.

Reba

[1] Gukurikirana ibice bya SARS-CoV-2 Byakuwe ku ya 24 Kamena 2021 bivuye kuri https://www.wowe.int/en/ibikorwa/kurikirana-SARS-CoV-2-variants/

2

Impinduka za Coronavirus zirimo gukwirakwira mu Buhinde - ibyo abahanga bazi kugeza ubu.Yakuwe ku ya 11 Gicurasi 2021, kuva https://www.umuco.com/articles/d41586-021-01274-7

[4] Impinduka za SARS-CoV-2 nimpungenge ziperereza mubwongereza.Yakuwe ku ya 25 Mata 2021, kuva, https://assets.publishing.service.gov.uk/ guverinoma

[5] Delta Variant ya Coronavirus Yashobora Kuganza Muri Amerika, Mubyumweru.Yakuwe ku ya 23 Kamena, avuye kuri https://www.npr.org/ibice/ubuzima-shusho/2021/06/22/1008859705/delta-variant-coronavirus-yakingiwe-us-covid-surge

[6] Yakuwe ku ya 26 Kamena 2021 avuye kuri https://www.ikinyamakuru.cn/amakuru Amakuru arambuye_yimbere_13296668

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[8] Ingaruka zinkingo za COVID-19 zirwanya B.1.617.2.Yakuwe ku ya 23 Gicurasi 2021, kuva kuri https://khub.net/inyandiko/135939561/430986542/Ingaruka+of+COVID-19+vaccines+yongeye +